Nickel-catalyzed reductive coupling of secondary alkyl bromides with alkynes to construct allylic difluoromethyl alkenes

Abstract

We report a highly efficient and broadly applicable nickel-hydride-catalyzed reductive cross-coupling of unactivated CF₂H-substituted electrophiles with diverse alkynes. The reaction proceeds with excellent catalytic efficiency and functional group tolerance, providing a powerful platform for the late-stage fluoroalkylation of complex drug molecules.