From the journal:

Chemical Communications

A mitochondria-anchored dual-lock probe for sequential detection of HOCl and viscosity during oxidative stress and ferroptosis

Xue Wu,†a   Yaran Yang,†a   Chenchun Zhou,a   Junjie Kou,a   Mingxia Li,a   Fanpeng Kong ORCID logo *a  and  Bo Tang ORCID logo ab  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, People's Republic of China
E-mail: kong-fanpeng@163.com

b Laoshan Laboratory, Qingdao 266237, Shandong, People's Republic of China

Abstract

We have developed a mitochondria-targeted and anchored dual-lock probe DHX-HOCl-V that is sequentially activated by HOCl and viscosity. This near-infrared probe exhibits excellent selectivity and low toxicity, and has been successfully applied for real-time imaging of mitochondrial HOCl and viscosity fluctuations during oxidative stress induced by drug stimulation or ferroptosis.

Graphical abstract: A mitochondria-anchored dual-lock probe for sequential detection of HOCl and viscosity during oxidative stress and ferroptosis

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Article information

DOI
https://doi.org/10.1039/D5CC06089C
Article type
Communication
Submitted
27 Oct 2025
Accepted
15 Dec 2025
First published
15 Dec 2025

Chem. Commun., 2026, Advance Article

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A mitochondria-anchored dual-lock probe for sequential detection of HOCl and viscosity during oxidative stress and ferroptosis

X. Wu, Y. Yang, C. Zhou, J. Kou, M. Li, F. Kong and B. Tang, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC06089C

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