Here, we present i-motif-functionalized glass nanopipettes that enable pH-triggered DNA release into single living cells. Acid-induced folding of the i-motif drives complementary strand dissociation through the ∼80 nm tip with minimal invasiveness. This pH-gated nanopipette enables reversible, on-demand single cell DNA delivery via rectification changes, establishing a potential platform for intracellular manipulation.
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S. Zheng, M. Wu, S. Zhang, M. Zhao, X. Liu, B. Chen, D. Li, R. Qian and J. Lv, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC05685C
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