From the journal:

Chemical Communications

A novel method for Tn antigen detection based on chemoenzymatic targeted labeling and CuAAC click chemistry

Hongxia Duan,   Lei Liu,   Xin Guo,   Zhongyu Wang,   Zheng Fang,   Huizhen Huang,   Hui Zhang,   Yanan Li,   Yan Wang,   Mingliang Ye,   Lingyun Jia  and  Mingming Dong  

Abstract

The Tn antigen is a key tumor-associated antigen and a promising cancer biomarker. However, its low abundance poses great challenges for sensitive detection. We developed a novel approach that integrates B3GNT6-mediated Tn-specific labelling, click chemistry, and chemiluminescent detection to enable quantitative and sensitive analysis of Tn antigen.

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Article information

DOI
https://doi.org/10.1039/D5CC05398F
Article type
Communication
Submitted
20 Sep 2025
Accepted
16 Dec 2025
First published
23 Dec 2025

Chem. Commun., 2026, Accepted Manuscript

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A novel method for Tn antigen detection based on chemoenzymatic targeted labeling and CuAAC click chemistry

H. Duan, L. Liu, X. Guo, Z. Wang, Z. Fang, H. Huang, H. Zhang, Y. Li, Y. Wang, M. Ye, L. Jia and M. Dong, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D5CC05398F

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