Regioselective functionalization of sulfenamides: S-arylation with cyclic diaryl λ3-bromanes and λ3-chloranes

Abstract

We report an S-selective and meta-regioselective arylation of sulfenamides with cyclic diaryl λ³-bromanes and λ³-chloranes. This metal-free strategy proceeds under mild conditions, tolerates diverse functional groups, and delivers S-aryl sulfilimines in good to excellent yields with high regioselectivity. The method is scalable, enabling scale-up synthesis and further transformations, highlighting the potential for efficient late-stage functionalization.