Peptide-based aggregation-induced emission fluorescent probe for rapid and accurate detection of low molecular weight heparin

Abstract

Monitoring low molecular weight heparin (LMWH) is essential in clinical practice. We present a peptide-based aggregation-induced emission fluorescent probe, Z-BTDPA-Pep, capable of rapid, sensitive, and selective detection of LMWH in serum (0.1–2.0 U ml⁻¹, LOD = 0.00378 U ml⁻¹). The results correlate well with the clinical gold-standard anti-Xa assay, highlighting its potential for real-time LMWH monitoring and safer clinical drug administration.