Direct Measurement Method for ⁹⁰Y Activity in Urine

Abstract

⁹⁰Y radioembolization is an effective therapeutic method for unresectable hepatocellular carcinoma. A small amount of ⁹⁰Y may detach from microspheres and be excreted in urine during treatment, and the accurate determination of ⁹⁰Y activity in urine is crucial for radiation safety assessment. The β-particles emitted by ⁹⁰Y have energy higher than the Cherenkov threshold, and its activity can be measured by liquid scintillation counting (LSC) and Cherenkov counting. This study explored the feasibility of direct determination of ⁹⁰Y activity in urine by comparing LSC and Cherenkov counting methods. The focus was placed on investigating the effect of urine color (light transmittance), and the background count, counting efficiency, minimum detectable activity and method accuracy were analyzed. The results showed that the counting efficiency of both methods was positively correlated with light transmittance.Under the same light transmittance condition, the counting efficiency of LSC was higher than that of Cherenkov counting. Cherenkov counting exhibited a lower background count and a smaller minimum detectable activity, with a more superior performance especially under the condition of high light transmittance. Verification with urine samples containing ⁹⁰Y in the range of 0.195-6.696 KBq/L demonstrated that both methods had reliable accuracy, with the maximum relative deviation of 1.79% for LSC and 2.05% for Cherenkov counting. This study provides technical support for the reliable detection of ⁹⁰Y in urine.