Tyrosinase is a key biomarker in melanoma, emphasizing the need for reliable detection. Here, we developed a ratiometric fluorescent probe that undergoes enzyme-triggered structural transformation, evidenced by HPLC and spectral changes. It enables sensitive analysis, inhibitor evaluation, and detection in spiked human serum, demonstrating potential for diagnostic applications.
M. Han, H. Choi, J. Cha, Y. Kim and S. H. Lee, Anal. Methods, 2026, Accepted Manuscript , DOI: 10.1039/D5AY01258A
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