A Nickel-Based Bipolar Electrochemiluminescence Platform for Glucose Detection

Abstract

A nickel-based multichannel bipolar electrochemiluminescence (BP-ECL) sensor was reported for the rapid and non-invasive detection of glucose in urine. The bipolar electrodes are fabricated using nickel, an inexpensive material with excellent catalytic activity, thereby reducing the cost of mass-scale device fabrication from the source. The detection mechanism relies on the glucose oxidase-mediated production of hydrogen peroxide, which proportionally enhances the luminol electrochemiluminescence (ECL) intensity. The optimized sensor exhibited a low detection limit of 0.1 μM and a linear response across the range of 1.0 to 500.0 μM, demonstrating excellent sensitivity and stability. The developed multichannel BP-ECL sensor can be powered with only two commercial alkaline batteries (~3.2 V) without the need for sophisticated instrumentation, highlighting its significant potential for point-of-care testing and home-based health monitoring. The overall system features low cost, simple operation, and fast response, offering a feasible technical solution for daily monitoring of chronic diseases and primary healthcare screening.