Dual Strategy Approach for an Aliphatic Nitrile Directing Group Assisted Palladium-Catalyzed meta-C–H Arylation/Acetoxylation of Arenes

Abstract

The meta-selective arylation of simple aliphatic nitirile-bearing arylmethanesulfonic acid derivatives under microwave-accelerated conditions has been developed. Also presents the meta-arylation of 3-phenylpropanoic acid esters tethered to a nitrile template under conventional heating conditions. Further, the feasibility of meta-acetoxylation has been tested. Moreover, the strategy was found suitable for achieving drug diversification.