Modular synthesis of sulfilimines via NFSI-mediated S-arylation of sulfenamides with naphthols, phenols and indoles †

Abstract

Sulfilimines were exploited as valuable moieties in organic synthesis and medicinal chemistry, however, efficient methods for constructing such scaffolds remain limited. Herein, we disclosed a convenient method for modular synthesis of structurally diverse sulfilimines through NFSI-mediated S-arylation of sulfenamides with naphthols, phenols and indoles at room temperature. This straightforward process proceeded smoothly under mild condition, with broad substrate scope and high overall efficiency. The potential synthetic merit of this protocol was further demonstrated through gram-scale reactions, product derivatization and late-stage modification of natural products and drugs.