Tetrahydroxydiboron-mediated radical cyclization of unactivated alkenes toward ring-fused quinazolinones

Abstract

A tetrahydroxydiboron-mediated radical cyclization of unactivated alkenes under photoinduced conditions was developed to synthesize the ring-fused quinazolinones for the first time. The concise, mild and photocatalyst- and oxidant-free conditions, as well as the good functional group tolerance, render this protocol a green and convenient strategy for the synthesis of polycyclic ring-fused quinazolinones. Mechanism studies indicated that the process might be involed a radical pathway. Mechanism studies suggest that the process is involved in a radical pathway.