Synthesis and Late-stage C-H Functionalization of Papaverines

Abstract

An efficient synthesis and late-stage C-H functionalization of papaverine under volatile solvent-free conditions are reported. This methodology demonstrates significant potential for applications in the active pharmaceutical ingredient (API) industry, particularly for the sustainable and solvent-free synthesis of papaverine. The plausible reaction mechanism was meticulously elucidated through comprehensive control experiments. Additionally, gram-scale synthesis of papaverine and its functionalized derivatives was successfully accomplished. Furthermore, the photophysical properties of the synthesized functionalized papaverine compounds were thoroughly investigated using absorption and emission spectroscopy.

Supplementary files

Article information

Article type
Communication
Submitted
17 Jul 2025
Accepted
29 Aug 2025
First published
30 Aug 2025

Org. Biomol. Chem., 2025, Accepted Manuscript

Synthesis and Late-stage C-H Functionalization of Papaverines

S. Suresh and F. Nawaz Khan, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB01155H

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