Rh(III)-catalyzed annulation of oxadiazolones with CF3-imidoyl sulfoxonium ylides: access to trifluoromethyl-substituted fused-dihydroisoquinolines

Abstract

A rhodium(III)-catalyzed redox-neutral C(sp2)–H bond activation and annulation of oxadiazolones and CF3-substituted imidoyl sulfoxonium ylides (TFISYs) has been developed. The cascade C(sp2)–H bond imidoylmethylation and subsequent intramolecular nucleophilic addition sequence might be involved in the transformation, providing a direct access to diverse trifluoromethyl and amino-containing fused-dihydroisoquinolines.