Copper-Promoted Late-Stage Glycosylsulfonylation of Aryl Iodide and Bromide to Access Glycosyl Aryl Sulfones

Abstract

Glycosyl aryl sulfones exhibit diverse biological activities. Herein, we developed a copper-promoted coupling strategy using glycosyl sodium sulfinates and aryl iodides or bromides, enabling efficient synthesis with broad functional group compatibility. This method offers a versatile approach for the late-stage modification of bioactive molecules.

Supplementary files

Article information

Article type
Paper
Submitted
27 Mar 2025
Accepted
08 May 2025
First published
15 May 2025

Org. Biomol. Chem., 2025, Accepted Manuscript

Copper-Promoted Late-Stage Glycosylsulfonylation of Aryl Iodide and Bromide to Access Glycosyl Aryl Sulfones

L. Wang, H. Guo, J. Luo, W. Zhen, S. Wang, Z. Xie and C. Xu, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB00509D

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