Copper-Promoted Late-Stage Glycosylsulfonylation of Aryl Iodide and Bromide to Access Glycosyl Aryl Sulfones
Abstract
Glycosyl aryl sulfones exhibit diverse biological activities. Herein, we developed a copper-promoted coupling strategy using glycosyl sodium sulfinates and aryl iodides or bromides, enabling efficient synthesis with broad functional group compatibility. This method offers a versatile approach for the late-stage modification of bioactive molecules.