Novel indolespiro bicoumarins: synthesis and their antifungal activity

Abstract

This article reports a spiro cyclic system that contains an oxoindole and two coumarin rings. Dozens of compounds with this structure have been synthesized, via a facile three-component reaction of isatin and 4-aminocoumarins, in yields up to 90%. The antifungal activity of several indolespiro[4H-pyrido[3,2-c][5,6-c]bicoumarins] has also been evaluated, with some of them showing good antifungal activity against Physalospora piricola.