Unconventional Approaches for Synthesis of 2-Substituted Benzothiazoles

Abstract

Benzothiazoles are one of the most important heterocycles in pharmaceuticals, natural products, and functional materials. Hence, the development of direct and sustainable routes by replacing hazardous/toxic thiol reagents with nontoxic participants for constructing 2-substituted benzothiazoles is a topic of utmost importance. In this review, we have highlighted many synthetic methods towards the synthesis of 2-substituted benzothiazoles from different starting materials under transition metal catalysis or metal-free systems.