A unified strategy to generate acyl radical from α-imino-oxy acids via selective C-C bond activation is reported. In the presence of silver catalyst, α-imino-oxy acids could undergo the decarboxylation, N-O and C-C bond homolysis to deliver the acyl radicals, which was subsequently captured by N-alkyl-N-aryl-2-(trifluoromethyl)acrylamides to access acylated 3-CF3-2-oxindoles.
Y. Cao, Y. Wei, Y. Hu, D. Liu, M. Liu, J. Wang, C. Li, P. Wang, L. Hu and F. Li, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB00262A
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...
