Alternating current enabled para-selective C(sp2)–H/N–H cross-coupling of aniline

Abstract

C–H/N–H coupling using electrochemistry and non-transition metal catalysis is a highly efficient method for atom and step economy. However, its synthesis remains a significant challenge because of issues related to the region selectivity and excessive oxidation of the resulting product. This study presents a novel approach to achieving para-selective amination of arylamines by employing alternating current (AC) polarity reversal and periodic electrode modulation to control excessive oxidation. The reaction was conducted in a straightforward one-piece reactor without the need for chemical oxidants and demonstrated broad substrate applicability.