Factors underlying sensitivity of aromatic oxalates in peroxyoxalate chemiluminescent reaction in aqueous-organic media

Abstract

Sensitivity and selectivity of aromatic oxalates towards H₂O₂ are proposed as key criteria for selecting substrates for chemiexcited photodynamic therapy (PDT). An increase in the electronegativity of the oxalate reduces both sensitivity and selectivity. The presence of an o-substituent increases the efficiency of aromatic oxalate. Oxalate encapsulation in micelles does not change the patterns observed in solution. The biocompatible bis(2-pentyloxycarbonyl-phenyl)oxalate, synthesized for the first time, is a promising oxalate for chemiexcited PDT.