From the journal:

Chemical Communications

Harnessing conserved G-quadruplexes for fluorescence detection of Mycobacterium tuberculosis

Vasudhar Bhat S. V.,†a   Sumon Pratihar,†a   Krithi K. Bhagavath,a   Mohamed Nabeel Mattath ORCID logo a  and  Thimmaiah Govindaraju ORCID logo *a  

* Corresponding authors

a Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur P.O., Bengaluru, 560064 Karnataka, India
E-mail: tgraju@jncasr.ac.in

Abstract

We report the fluorescence detection of the conserved G-quadruplex (GQ) motif in Mycobacterium tuberculosis (MTB) DNA, ensuring high specificity with minimal interference from human and non-MTB DNA sequences. The duplex-to-GQ reliable conformational polymorphism (GQ-RCP) enables its application in amplification-compatible MTB detection, offering a platform for precise diagnostic assays.

Graphical abstract: Harnessing conserved G-quadruplexes for fluorescence detection of Mycobacterium tuberculosis

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D5CC04932F
Article type
Communication
Submitted
27 Aug 2025
Accepted
08 Sep 2025
First published
09 Sep 2025

Chem. Commun., 2025, Advance Article

Permissions

Request permissions

Harnessing conserved G-quadruplexes for fluorescence detection of Mycobacterium tuberculosis

V. B. S. V., S. Pratihar, K. K. Bhagavath, M. N. Mattath and T. Govindaraju, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC04932F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements