Biomimetic synthesis of a benzobisthiazole-based conjugated polymer for pH-responsive drug delivery and synergistic tumor therapy

Kun Zhang; Yu Wu; Qi Lai; Peng Luo; Xin Hu; Meiying Liu; Yulong Ouyang; Shaorong Huang; Xiaoyong Zhang; Yen Wei

doi:10.1039/D5CC04705F

Biomimetic synthesis of a benzobisthiazole-based conjugated polymer for pH-responsive drug delivery and synergistic tumor therapy

Kun Zhang,†^ac Yu Wu,†^ab Qi Lai,^b Peng Luo,^ab Xin Hu,^d Meiying Liu,^d Yulong Ouyang,*^b Shaorong Huang,*^c Xiaoyong Zhang

*^a and Yen Wei^e

Author affiliations

* Corresponding authors

^a Department of Chemistry, Nanchang University, Nanchang, Jiangxi province, China

^b Orthopedic Hospital, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17 Yong Wai Zheng Street, Nanchang, Jiangxi 330006, China
E-mail: ndyfy10126@ncu.edu.cn

^c Institute of Geriatrics, Jiangxi Provincial People's Hospital &, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, People's Republic of China
E-mail: huangshaorong@ncmc.edu.cn

^d Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China

^e Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing, P. R. China

Abstract

A benzodithiophene-based conjugated polymer (termed as DPDMP) with high water-dispersibility, biocompatibility, and superior photothermal conversion efficiency was synthesized using a biomimetic click reaction. DPDMP can establish pH-responsive boronate ester bonds with bortezomib, enabling an integrated approach to tumor photothermal and chemotherapy.

Chemical Communications

Biomimetic synthesis of a benzobisthiazole-based conjugated polymer for pH-responsive drug delivery and synergistic tumor therapy

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Biomimetic synthesis of a benzobisthiazole-based conjugated polymer for pH-responsive drug delivery and synergistic tumor therapy

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