SCHEDULED MAINTENANCE:
We report a novel methodology for the site-selective chalcogenation of peptides via Pd-catalyzed β-C(sp3)-H activation. In this study, native methionine residues serve as an intrinsic directing group, while various diaryl disulfides/diselenides act as coupling parterner, affording chalcogenated peptides in moderate to good isolated yields.
J. Tang, Q. Lu, F. Lu, Y. Sun, Y. Pan and W. Qu, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC04285B
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