Oxidation of Dihydrotetrazine Triggered by Near Infrared Photocatalysis for Photoclick Chemistry

Abstract

Using biocompatible near-infrared light to trigger click reactions offers a powerful approach for achieving spatiotemporal control in bioconjugate chemistry. This study demonstrates the photooxidation of dihydrotetrazine at 810 nm using cyanine as a photocatalyst to unlock the tetrazine function. This activation enables the inverse electron-demand Diels-Alder reaction with strained alkenes