Dearomatizative Aminoetherification and Diamination of Indoles Enabled by Photochemical Nitrene Transfer Reactions

Abstract

In this study, we report a catalyst free, dearomatizative aminoetherification and diamination of indoles by using photo-promoted nitrene transfer reaction as the key step. A wide range of indoline scaffolds can be obtained in moderate to good yields. The approach can be further applied to the synthesis of three kinds of bioactive polycyclic ring structures. A series of mechanistic experiments well supports the proposed nitrene transfer process.