Acetyl-coenzyme A is a universal coenzyme involved in diverse biochemical reactions, including histone acetylation catalysed by histone lysine acetyltransferases. Combined enzyme assays and molecular dynamics simulations demonstrate that the 3’-phosphate group of acetyl-coenzyme A is important, but not essential, for productive histone lysine acetyltransferase catalysis.
N. Bilgin, L. Moesgaard, G. Proietti, J. Kongsted and J. Mecinović, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC01562F
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