Oxygen self-supplying porphyrinic MOFs to alleviate tumor hypoxia for starvation-amplified photodynamic therapy

Shajun Zhu; Jian An; Jia Pu; Xufeng Liang; Shiyue Zhang; Jingjing Ma; Jianxia Zhang; Yujia Meng; Yiqiao Bai; Wenqiang Yu; Yunhan Gao; Yong Yao; Tingting Chen; Yang Wang

doi:10.1039/D5CC00278H

Oxygen self-supplying porphyrinic MOFs to alleviate tumor hypoxia for starvation-amplified photodynamic therapy†

Shajun Zhu,^a Jian An,^b Jia Pu,^b Xufeng Liang,^b Shiyue Zhang,^b Jingjing Ma,^b Jianxia Zhang,^b Yujia Meng,^b Yiqiao Bai,^b Wenqiang Yu,^b Yunhan Gao,^b Yong Yao,

^b Tingting Chen*^b and Yang Wang

*^b

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* Corresponding authors

^a Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P. R. China

^b School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019, P. R. China
E-mail: ywang85@ntu.edu.cn, chentingting@ntu.edu.cn

Abstract

An oxygen self-supplying nanoplatform utilizing perfluorocarbon-functionalized porphyrinic MOFs was developed to alleviate tumor hypoxia. This strategy combines external oxygen-delivery with in situ oxygen generation via cascade reactions, resulting in enhanced synergistic effects for both cancer starvation therapy and robust photodynamic therapy.

Chemical Communications

Oxygen self-supplying porphyrinic MOFs to alleviate tumor hypoxia for starvation-amplified photodynamic therapy†

Abstract

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Oxygen self-supplying porphyrinic MOFs to alleviate tumor hypoxia for starvation-amplified photodynamic therapy

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