Structure-function relationship of S protein cleavage in cowpea mosaic virus intratumoral immunotherapy

Andrea Simms; Jessica Fernanda Affonso de Oliveira; Narek Minasov; Edward Cedrone; Marina A. Dobrovolskaia; Nicole F. Steinmetz

doi:10.1039/D5BM00969C

Structure-function relationship of S protein cleavage in cowpea mosaic virus intratumoral immunotherapy

Andrea Simms,

^abcd Jessica Fernanda Affonso de Oliveira,

^abcd Narek Minasov,^abcd Edward Cedrone,^e Marina A. Dobrovolskaia

^e and Nicole F. Steinmetz

*^abcdfghi

Author affiliations

* Corresponding authors

^a Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA
E-mail: nsteinmetz@ucsd.edu

^b Center for Nano-ImmunoEngineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA

^c Moores Cancer Center, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA

^d Shu and K.C. Chien and Peter Farrell Collaboratory, University of California, 9500 Gilman Dr., La Jolla, CA, USA

^e Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, 8560 Progress Dr., Frederick, MD, USA

^f Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA

^g Department of Radiology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA

^h Institute for Materials Discovery and Design, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA

ⁱ Center for Engineering in Cancer, Institute for Engineering in Medicine, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA, USA

Abstract

Translational studies are underway for cowpea mosaic virus (CPMV) as a candidate for intratumoral immunotherapy. To further strengthen the argument for translation, here we demonstrate that a structural deviation in CPMV's small (S) coat protein does not negatively impact its antitumor efficacy, immune cell uptake, or cytokine profile.

This article is part of the themed collection: Materials Developments in Cancer Therapeutics

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DOI: https://doi.org/10.1039/D5BM00969C
Article type: Paper
Submitted: 25 Jun 2025
Accepted: 04 Aug 2025
First published: 26 Aug 2025

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Biomater. Sci., 2025, Advance Article

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Structure-function relationship of S protein cleavage in cowpea mosaic virus intratumoral immunotherapy

A. Simms, J. F. Affonso de Oliveira, N. Minasov, E. Cedrone, M. A. Dobrovolskaia and N. F. Steinmetz, Biomater. Sci., 2025, Advance Article , DOI: 10.1039/D5BM00969C

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Biomaterials Science

Structure-function relationship of S protein cleavage in cowpea mosaic virus intratumoral immunotherapy

Abstract

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Structure-function relationship of S protein cleavage in cowpea mosaic virus intratumoral immunotherapy

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