Development of a NS-CDs/Fluorescein Ratiometric Fluorescent Sensor Integrated Smartphone Platform for Rapid and Specific Detection of Mn(VII) and Captopril

Abstract

The construction of a ratiometric fluorescent sensor based on nitrogen-doped carbon dots (NS-CDs) and fluorescein was reported to detect Mn(VII) and captopril. The detection mechanism of Mn(VII) and captopril were based on inner filter effect (IFE) and redox reaction, respectively. The sensor showed good linearities in the detection range of 0.12-100 μM for Mn(VII) and 0.52-300 μM for captopril, with limits of detection (LODs) of 0.12 μM and 0.52 μM, respectively. Furthermore, a smartphone-based platform for the detection of Mn(VII) and captopril was developed, based on the dual-signal response of color and fluorescence intensity. The system displayed linear signal changes with increasing Mn(VII) and captopril concentration in the ranges of 0.32-100 μM and 0.52-300 μM, with LODs of 0.32 μM and 0.52 μM, respectively. Finally, the ratiometric sensor was validated for the determination of Mn(VII) and captopril in herb and captopril tablet samples, demonstrating its broad applicability and versatility as a portable, sensitive, and specific detector for Mn(VII) and captopril in various sample types. Overall, our ratiometric fluorescent sensor has potential as a portable, on-site detector for Mn(VII) and captopril analysis.