Electrochemically mediated synthesis of trifluoromethylallenes

Abstract

Fluoroalkylated allenes are potential compounds for drug and materials development. Herein, we report electrochemically mediated trifluoromethylallene synthesis through the rearrangement of trifluoromethyl-containing 1,3-enynes under the action of silicon or boron radicals. A series of late functionalization reactions of natural product derivatives were explored to generate corresponding complex allylsilane compounds, and the transformation of homoallenylborates synthesized useful building blocks.