Continuous-flow Directed C–H Amidation Reactions Using Immobilized Cp*Rh(III) Catalysts

Abstract

We report a green, continuous-flow C–H amidation methodology using heterogeneous Cp*Rh(III) catalysts. These catalysts enable halide- and salt-free reactions with excellent activity and durability across diverse substrates, demonstrated by a 200-hour, multi-gram scale reaction exceeding 290 TON (turnover number).