Issue 40, 2024

Automated exploration of the conformational degrees of freedom along reaction profiles - driving a FASTCAR

Abstract

This publication aims at presenting a Python-based workflow designed to enable a fully automatised and exhaustive exploration of the conformational degrees of freedom within the calculation of reaction paths in molecular systems. The proposed strategy focuses on effectively representing the lowest energy conformers for intricate, highly rotatable, and non-intuitive transition states, reagents and products, using existing computational tools. The article presents a workflow that is demonstrated through the application of five chemical reactions, chosen to be representative of the diversity and complexity of actual experimental studies, and which often prove to be challenging to study “by hand”. The proposed methodology is expected to be of a great help in the modelling of state-of-the art organic chemistry reactions, whose complexity is ever increasing.

Graphical abstract: Automated exploration of the conformational degrees of freedom along reaction profiles - driving a FASTCAR

Supplementary files

Article information

Article type
Paper
Submitted
26 Apr 2024
Accepted
26 Jul 2024
First published
30 Jul 2024

Phys. Chem. Chem. Phys., 2024,26, 25780-25787

Automated exploration of the conformational degrees of freedom along reaction profiles - driving a FASTCAR

O. Gayraud, B. Courbière and F. Guégan, Phys. Chem. Chem. Phys., 2024, 26, 25780 DOI: 10.1039/D4CP01721H

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