Suraj Singh, Rohtash Kumar, Navneet Nandgopal Dubey and Chandrakumar Appayee
Chem. Commun., 2024,60, 8768-8771
DOI:
10.1039/D4CC03132F,
Communication
The first synthesis of chiral cis-2,5-disubstituted pyrrolidine organocatalysts is described. Their application for the enantioselective Michael addition of nitromethane to α,β-unsaturated aldehydes with excellent yield (up to 91%) and enantioselectivity (up to >99% ee) is demonstrated. Another catalytic application for the reaction of 2,4-hexadienal with nitrostyrene is also showcased.
