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A new antibacterial system (HG) based on the host–guest chemistry between pillar[5]arene and a zwitterionic guest was fabricated. The HG complex displayed excellent antibacterial and biofilm formation inhibition and dispersal activities against E. coli, S. aureus and MRSA.

Graphical abstract: Construction of a supramolecular antibacterial material based on water-soluble pillar[5]arene and a zwitterionic guest molecule

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