Sequential ortho-/meta-C–H functionalizations of N-tosyl-benzamides for the synthesis of polyfunctionalized arenes

Abstract

Selective one-pot sequential ortho-/meta-C–H functionalizations provided highly desirable polyfunctionalized arenes. Starting from readily available carboxylic acid derivatives, the concomitant formation of C–O and C–halogen bonds was achieved under mild reaction conditions (12 examples, up to 75% yield). The utility of the products was illustrated with post-functionalization reactions and Metiglinid synthesis.