Aradhana Sahoo, Shubham Dutta and Akhila K. Sahoo
Org. Biomol. Chem., 2023,21, 5737-5741
DOI:
10.1039/D3OB00793F,
Communication
The present study describes a method for the dicarbofunctionalization of ynamide via a palladium-catalyzed two-component diarylation with aryl boronic acids. The reaction involves a consecutive transmetalation of the aryl boronic acids with a Pd(II)-complex making the transformation stereoselective. Importantly, the reaction proceeds under mild conditions and tolerates a broad range of functional groups. Control experiments validate the role of the oxidant (useful for catalyst regeneration) in the reaction mechanism.