Enabling a universal lateral flow readout for DNA strand displacement via disassembling chemical labels

Wanting Peng; Yun Tan; Chenlan Shen; Yanan Tang; Feng Li

doi:10.1039/D3CC01743E

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Enabling a universal lateral flow readout for DNA strand displacement via disassembling chemical labels†

Wanting Peng,‡^a Yun Tan,‡^a Chenlan Shen,^b Yanan Tang*^a and Feng Li

*^ab

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* Corresponding authors

^a Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Analytical & Testing Center, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, P. R. China
E-mail: windtalker_1205@scu.edu.cn

^b Department of Laboratory Medicine, Med + X Center for Manufacturing, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China

Abstract

Herein, we describe a novel strategy that enables lateral flow readout for DNA strand displacement via disassembling chemical labels (DCL). Comparing it to a classic fluorogenic assay, we demonstrate that our DCL-based lateral flow assay is highly sensitive and specific, capable of discriminating single nucleotide variants in buccal swab samples.

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Article information

DOI: https://doi.org/10.1039/D3CC01743E
Article type: Communication
Submitted: 10 Apr 2023
Accepted: 21 Jun 2023
First published: 21 Jun 2023

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Chem. Commun., 2023,59, 8803-8805

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Enabling a universal lateral flow readout for DNA strand displacement via disassembling chemical labels

W. Peng, Y. Tan, C. Shen, Y. Tang and F. Li, Chem. Commun., 2023, 59, 8803 DOI: 10.1039/D3CC01743E

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Chemical Communications

Enabling a universal lateral flow readout for DNA strand displacement via disassembling chemical labels†

Abstract

Supplementary files

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Enabling a universal lateral flow readout for DNA strand displacement via disassembling chemical labels

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