Issue 36, 2023
From the journal:

Chemical Communications

Tetralactam macrocycle based indicator displacement assay for colorimetric and fluorometric dual-mode detection of urinary uric acid†

Huan Yao,‡a   Shi-Yao Li,‡a   Hong Zhang,b   Xin-Yu Pang,b   Jia-Le Lu,a   Cong Chen,c   Wei Jiang, ORCID logo §b   Liu-Pan Yang ORCID logo *a  and  Li-Li Wang*a  

* Corresponding authors

a School of Pharmaceutical Science, Postdoctoral Research Station of Basic Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
E-mail: yanglp@usc.edu.cn, wangll@usc.edu.cn

b Department of Chemistry, Southern University of Science and Technology, Xueyuan Blvd 1088, Shenzhen, China

c Department of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China

Abstract

An indicator displacement assay for colorimetric and fluorometric dual-mode detection of urinary uric acid (UA) was constructed using a water-soluble naphthalene-based tetralactam macrocycle and the phenoxazine dye, resorufin (RF). The visual detection of UA levels of volunteers was successfully realized using modified paper assays, which could be used for the home monitoring of urinary UA.

Graphical abstract: Tetralactam macrocycle based indicator displacement assay for colorimetric and fluorometric dual-mode detection of urinary uric acid

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Article information

DOI
https://doi.org/10.1039/D2CC06622J
Article type
Communication
Submitted
05 Dec 2022
Accepted
29 Mar 2023
First published
29 Mar 2023

Chem. Commun., 2023,59, 5411-5414

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Tetralactam macrocycle based indicator displacement assay for colorimetric and fluorometric dual-mode detection of urinary uric acid

H. Yao, S. Li, H. Zhang, X. Pang, J. Lu, C. Chen, W. Jiang, L. Yang and L. Wang, Chem. Commun., 2023, 59, 5411 DOI: 10.1039/D2CC06622J

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