A cysteine-activated fluorescent H2S donor for visualizing H2S release and alleviating cellular inflammation

Abstract

We developed Bcy-NCS, a Cys-specific fluorescent H2S donor with a self-immolative spacer, overcoming the issue of multiple fluorophore release seen in traditional ICT-based donors. Bcy-NCS selectively responds to Cys, releases H2S, and enables fluorescence-based monitoring. It also reduces LPS-induced inflammation in RAW 264.7 cells, indicating potential for inflammation treatment.

Supplementary files

Article information

Article type
Communication
Submitted
09 Sep 2024
Accepted
28 Oct 2024
First published
29 Oct 2024

Chem. Commun., 2024, Accepted Manuscript

A cysteine-activated fluorescent H2S donor for visualizing H2S release and alleviating cellular inflammation

N. Wang, X. Wang, J. Wang, Y. Ren, H. Hua and D. Li, Chem. Commun., 2024, Accepted Manuscript , DOI: 10.1039/D4CC04655B

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