Magnetoresponsive biocomposite hydrogels comprising of gelatin and valine based magnetic ionic liquid surfactant as controlled release nanocarrier for drug delivery

Utilization of biopolymer hydrogels has been challenging due to the lack of controllability, actuation, and quick-response properties. Herein, we report a strategic nanoparticle-free approach towards magneto-responsive biocomposite hydrogels by combining...


18.
Table S2 Comparison of previously reported orinidazole drug loading efficiency in various systems.

19.
Table S3 Comparison of previously reported 5-Fluorouracil drug loading efficiency in various systems.

20.
Table S4 Kinetics study of drug release pattern using mathematical models.
where, C 20 is the concentration reduce by 20mNm -1 from the surface tension of the solvent (water) 1

1 .
Fig. S17 Drug release pattern in different electrolyte solution Annexure I Derived surface parameters using conductivity, surface tension and pyrene fluorescence measurements and their equations.16 Annexure II Various mathematical models for drug release pattern for ornidazole and 5-fluorouracil.17 Structural scheme of synthesized [ValC 16 ][FeCl 4 ].
Fig. S17 Drug release pattern in different electrolyte solution

3 . 1 .
Minimum area occupied by monomers at the interface was calculated using equation 4. ) 3 ( .......... .......... .......... .......... .......... .N A is Avogadro number and the Unit of A min is Å 2 .4. The β value is obtained from the formula (β =1-α) where the α is the degree of counterion dissociation which is obtained by ratio of the slope post micellar region and the pre micellar region (S 2 /S 1 ) then the β value is further used to derive the value of standard free energy of micellization from the equation as follow: …………….(4) Zero order mathematical model: C o -C t =K o t where C o = intial concentration of the drug at time, t = 0, C t = amount of drug released at time t, K o = zero order constant 2. First Order mathematical model: lnC = lnC o -K 1 t where C o = intial concentration of the drug at time K 1 = first order rate constant, C = percent of drug remaining at time 3. Higuchi model:  =  (2 -) Q=Cumulative amount of drug released at time per unit area, C S is the drug solubility in the matrix and D is the diffusion coefficient of the drug molecule in the matrix, C S =drug solubility in the matrix.4. Korsmeyer-Peppas model M t /M ∞ =K kp t n Mt = amount of drug released in time t, M∞ = amount of drug released after time ∞, n = diffusional exponent or drug release exponent, and K kp = Korsmeyer release rate constant.5. Hixson-Crowell model  1/3 0 - 1/3  =    K HC = Hixson-Crowell constant References

Table S2
Comparison of previously reported ornidazole drug loading efficiency in various systems.

Comparison of previously reported 5-Fluoro uracil drug loading efficiency in various systems. Table S3
Comparison of previously reported 5-Fluoro uracil drug loading efficiency in various systems.

Table S4 :
Kinetics study of release of guest drugs by various mathematical models.