Lite Version|Standard version

To gain access to this content please
Log in with your free Royal Society of Chemistry publishing personal account.
Log in via your home Institution.
Log in with your member or subscriber username and password.
Download

A novel TsCl-mediated domino sequence to expeditiously access quinolone-based antibiotics, such as ciprofloxacin, norfloxacin, pefloxacin, oxilinic acid, ivacaftor and the precursor of grepftfloxacin and ozenoxacin, starting from commercially available chromone-3-carboxaldehydes and amines, was developed. The total synthesis of these quinolone-based drugs via this sequence shortens the original seven/eight step synthesis to three/four steps with a high overall yield under environmentally benign conditions. The quinolone-based antibiotic drug analogues could also be efficiently synthesized by varying the starting materials and chemical reagents for discovering and developing new antibiotics.

Graphical abstract: Practical synthesis of quinolone drugs via a novel TsCl-mediated domino reaction sequence

Page: ^ Top