Issue 24, 2022

Dietary intervention in depression – a review

Abstract

Depression is a mental illness that affects the normal lives of over 300 million people. Unfortunately, about 30% to 40% of patients do not adequately respond to pharmacotherapy and other therapies. This review focuses on exploring the relationship between dietary nutrition and depression, aiming to find safer and efficient ingredients to alleviate depression. Diet can affect depression in numerous ways. These pathways include the regulation of tryptophan metabolism, inflammation, hypothalamic–pituitary–adrenal (HPA) axis, microbe–gut–brain axis, brain-derived neurotrophic factor (BDNF) and epigenetics. Furthermore, probiotics, micronutrients, and other active substances exhibit significant antidepressant effects by regulating the above pathways. These provide insights for developing antidepressant foods.

Graphical abstract: Dietary intervention in depression – a review

Article information

Article type
Review Article
Submitted
20 Sep 2022
Accepted
04 Nov 2022
First published
14 Nov 2022

Food Funct., 2022,13, 12475-12486

Dietary intervention in depression – a review

T. Wu, R. Liu, L. Zhang, M. Rifky, W. Sui, Q. Zhu, J. Zhang, J. Yin and M. Zhang, Food Funct., 2022, 13, 12475 DOI: 10.1039/D2FO02795J

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