A platinum-based fluorescent “turn on” sensor to decipher the reduction of platinum(iv) prodrugs

Abstract

We report a strategy to use a fluorescence “turn on” sensor to quantify the reduction of platinum(IV) prodrugs in a real-time mode by simply and conveniently monitoring the fluorescence intensity. Proteins with high molecular weights, especially those between 10 and 100 kDa, contribute more to the reduction of the platinum(IV) complex in cell extracts.