Issue 29, 2014
From the journal:

RSC Advances

Synthesis of RAFT polymers as bivalent inhibitors of cholera toxin†

David J. Leaver,ab   Andrew B. Hughes,a   Raymond M. Dawson,c   Almar Postma,b   Nino Malicb  and  Anastasios Polyzos*b  

* Corresponding authors

a Department of Chemistry, La Trobe University, Melbourne, Victoria 3086, Australia

b CSIRO Materials Science and Engineering, Bayview Avenue, Clayton South, Victoria 3169, Australia
E-mail: tash.polyzos@csiro.au

c DSTO Melbourne, Defence Science and Technology Organisation, P.O. Box 4331, Melbourne, Victoria 3001, Australia

Abstract

We report a new strategy to develop low molecular weight (18–28 kDa) poly(N-acryloylmorpholine) (PNAM) polymers as bivalent inhibitors of cholera toxin (CT) using Reversible Addition–Fragmentation chain Transfer (RAFT) technology. The inhibitory activity of the galacto-conjugated polymers was examined (ELISA) and the series displayed moderate inhibitory activity (millimolar IC50).

Graphical abstract: Synthesis of RAFT polymers as bivalent inhibitors of cholera toxin

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Article information

DOI
https://doi.org/10.1039/C3RA47500J
Article type
Communication
Submitted
11 Dec 2013
Accepted
10 Mar 2014
First published
21 Mar 2014

RSC Adv., 2014,4, 14868-14871

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Synthesis of RAFT polymers as bivalent inhibitors of cholera toxin

D. J. Leaver, A. B. Hughes, R. M. Dawson, A. Postma, N. Malic and A. Polyzos, RSC Adv., 2014, 4, 14868 DOI: 10.1039/C3RA47500J

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