Issue 29, 2022

Continuous-flow synthesis of alkyl zinc sulfinates for the direct photofunctionalization of heterocycles

Abstract

A sustainable strategy for the alkylation of heterocycles is presented. The protocol relies on the in situ generation and further in-line use of alkyl zinc sulfinates through a continuous-flow system. The environmentally friendly character of the protocol is assured by the use of a green solvent mixture, the presence of a metal free oxidant and low waste generation.

Graphical abstract: Continuous-flow synthesis of alkyl zinc sulfinates for the direct photofunctionalization of heterocycles

Supplementary files

Article information

Article type
Communication
Submitted
21 Feb 2022
Accepted
14 Mar 2022
First published
14 Mar 2022

Chem. Commun., 2022,58, 4611-4614

Continuous-flow synthesis of alkyl zinc sulfinates for the direct photofunctionalization of heterocycles

J. L. Nova-Fernández, M. J. García, L. Mollari, G. Pascual-Coca, S. Cabrera and J. Alemán, Chem. Commun., 2022, 58, 4611 DOI: 10.1039/D2CC01065H

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