We describe a palladium-catalyzed reductive Heck cyclization of alkene-tethered carbamoyl chlorides. Notable features of this transformation include its robust scalability and good functional group tolerance. The utility of this approach is further underscored by its successful adaptation to one-pot procedures, offering diverse synthetic pathways to the medicinally relevant architectures.
J. Pan, Z. Wang, B. Li, C. Ni and C. Chen, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D6OB00032K
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