A lysosomal fluorescent probe for the imaging of viscosity in tumoral ferroptosis and rheumatoid arthritis mice models

Abstract

Viscosity, as an important micro-environment parameter, is closely related to the occurrence and progression of various diseases. Herein, we have developed a novel fluorescent probe (BIB) for lysosomal viscosity detection. Interestingly, using BIB, in vivo imaging of viscosity fluctuations in tumoral ferroptosis and rheumatoid arthritis models has been successfully achieved.

Graphical abstract: A lysosomal fluorescent probe for the imaging of viscosity in tumoral ferroptosis and rheumatoid arthritis mice models

Supplementary files

Article information

Article type
Communication
Submitted
29 May 2025
Accepted
18 Jul 2025
First published
18 Jul 2025

Chem. Commun., 2025, Advance Article

A lysosomal fluorescent probe for the imaging of viscosity in tumoral ferroptosis and rheumatoid arthritis mice models

H. Wang, B. Lin, Q. Zan, R. Wang, Y. Yang, S. Shuang, C. Dong, X. Yang and L. Fan, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC03040D

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