A near-infrared fluorescent probe for imaging peroxynitrite levels in paw edema mice and drug evaluation

Ling Hu; Si-Si Chen; Hui Zhang; Jing-Jing Chao; Zhen-Zhen Peng; Guo-Jiang Mao; Liufang Hu; Juan Ouyang; Anjie Min; Chun-Yan Li

doi:10.1039/D4CC01562B

A near-infrared fluorescent probe for imaging peroxynitrite levels in paw edema mice and drug evaluation†

Ling Hu,^a Si-Si Chen,^a Hui Zhang,^a Jing-Jing Chao,^a Zhen-Zhen Peng,^a Guo-Jiang Mao,^c Liufang Hu,^a Juan Ouyang,^a Anjie Min*^b and Chun-Yan Li

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, Hunan Provincial University Key Laboratory for Environmental and Ecological Health, College of Chemistry, Xiangtan University, Xiangtan, P. R. China
E-mail: lichunyan@xtu.edu.cn

^b Department of Oral and Maxillofacial Surgery, Center of Stomatology, Research Center of Oral and Maxillofacial Tumor, Insititute of Oral Cancer and Precancerous Lesions, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, P. R. China
E-mail: william0732@csu.edu.cn

^c Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, P. R. China

Abstract

A near-infrared fluorescent probe (TX-P) for detecting peroxynitrite is constructed. The probe has a near-infrared emission (725 nm), large Stokes shift (125 nm) and excellent sensitivity and selectivity. In addition, TX-P can be used to visualize ONOO⁻ in living cells, image ONOO⁻ in paw edema mice and evaluate anti-inflammatory drugs.

Chemical Communications

A near-infrared fluorescent probe for imaging peroxynitrite levels in paw edema mice and drug evaluation†

Abstract

Supplementary files

Article information

Download Citation

Permissions

A near-infrared fluorescent probe for imaging peroxynitrite levels in paw edema mice and drug evaluation

Social activity

Search articles by author

Spotlight

Advertisements