Electrochemical stereoselective borylation of Morita–Baylis–Hillman adducts to functionalized allylic boronates

Abstract

Herein, we disclose a highly efficient and facile electrochemical borylation of Morita–Baylis–Hillman adducts without using any metal catalyst. This methodology demonstrates excellent regio- and stereo-selectivity, leading to a wide range of functionalized E-allylic boronates, including derivatives of ibuprofen and menthol. Under mild and straightforward conditions, this redox-neutral reaction, combined with the scalability and synthetic applications of the allylic boronate esters, underscores its potential for a wide range of applications in organic synthesis.