Issue 39, 2021

Emerging nanomaterials applied for tackling the COVID-19 cytokine storm

Abstract

During the global outbreak of coronavirus disease 2019 (COVID-19), a hyperinflammatory state called the cytokine storm was recognized as a major contributor to multiple organ failure and mortality. However, to date, the diagnosis and treatment of the cytokine storm remain major challenges for the clinical prognosis of COVID-19. In this review, we outline various nanomaterial-based strategies for preventing the COVID-19 cytokine storm. We highlight the contribution of nanomaterials to directly inhibit cytokine release. We then discuss how nanomaterials can be used to deliver anti-inflammatory drugs to calm the cytokine storm. Nanomaterials also play crucial roles in diagnostics. Nanomaterial-based biosensors with improved sensitivity and specificity can be used to detect cytokines. In summary, emerging nanomaterials offer platforms and tools for the detection and treatment of the COVID-19 cytokine storm and future pandemic.

Graphical abstract: Emerging nanomaterials applied for tackling the COVID-19 cytokine storm

Article information

Article type
Review Article
Submitted
29 Jun 2021
Accepted
19 Aug 2021
First published
16 Sep 2021

J. Mater. Chem. B, 2021,9, 8185-8201

Emerging nanomaterials applied for tackling the COVID-19 cytokine storm

X. Yang, J. You, Y. Wei, H. Li, L. Gao, Q. Guo, Y. Huang, C. Gong and C. Yi, J. Mater. Chem. B, 2021, 9, 8185 DOI: 10.1039/D1TB01446C

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